Drug Glossary

Complete database of oncology medications

1538
Total Drugs
17
Chemotherapy
88
Targeted Therapy
107
Immunotherapy

Treatment Regimens

Standard chemotherapy combinations for colorectal cancer

FOLFOX 3 Drugs · 1st line, Adjuvant FOLFIRI 3 Drugs · 1st line, 2nd line CAPOX/XELOX 2 Drugs · 1st line, Adjuvant FOLFOXIRI 4 Drugs · 1st line FOLFOX + Bev 4 Drugs · 1st line FOLFIRI + Bev 4 Drugs · 1st line, 2nd line FOLFIRI + Cetux 4 Drugs · 1st line, 2nd line FOLFIRI + Pani 4 Drugs · 1st line, 2nd line FOLFOXIRI + Bev 5 Drugs · 1st line Cape mono 1 Drugs · Adjuvant, Maintenance Pembro 1 Drugs · 1st line Enco + Cetux 2 Drugs · 2nd line+ T + P (HER2) 2 Drugs · 3rd line+ TAS-102 / Lonsurf 2 Drugs · 3rd line+
FDA Approval Timeline for CRC
1950
Radiotherapy DNA, cellular water molecules
1952
Leucovorin
1953
Methotrexate Dihydrofolate reductase
1955
Acetaminophen Cyclooxygenase enzymes (COX-1, COX-2)
Prednisone Glucocorticoid receptor
1956
Indocyanine green
1958
Dexamethasone Glucocorticoid receptor
1959
Cyclophosphamid
Cyclophosphamide
1960
Bisacodyl Enteric nervous system receptors
Fleet
1961
Nsaid COX-1, COX-2
1962
5-fluorouracil
Fluorouracil
1963
Bupivacaine Voltage-gated sodium channels
Gastrografin
1964
Melphala
Neomyci Bacterial 30S ribosomal subunit
1970
Floxuridine Thymidylate synthase
1971
Saline
1972
Bupivacain Voltage-gated sodium channels
1974
Doxorubicin DNA, Topoisomerase II
Mitomycin
1976
Loperamide Mu-opioid receptors
1978
Cisplatin
1985
Golytely
Midazolam GABA-A receptors
1986
Interferon Interferon receptors (IFNAR1/IFNAR2 for alpha interferon, IFNGR1/IFNGR2 for gamma interferon)
1989
Omeprazole H+/K+-ATPase proton pump
Propofol GABA-A receptors
1990
Glutamine
1991
Filgrastim G-CSF receptor (CSF3R)
G-csf G-CSF receptor
Ondansetro 5-HT3 receptors
Ondansetron 5-HT3 receptors
Sargramostim GM-CSF receptor
1992
Aldesleukin IL-2 receptor
Desflurane GABA-A receptors, NMDA receptors
Paclitaxel
1993
Enoxaparin Factor Xa, Factor IIa (thrombin)
1995
Sevoflurane GABA receptors, glycine receptors
1996
Docetaxel β-tubulin, microtubules
Gemcitabine DNA synthesis, ribonucleotide reductase
Irinotecan Topoisomerase I
Ropivacaine Voltage-gated sodium channels
1998
Capecitabine
Infliximab TNF-α
1999
Dexmedetomidine Alpha-2 adrenergic receptors
2000
Tinzapari Antithrombin III, Factor Xa
Tinzaparin Factor Xa, Thrombin
2001
Tegafu Thymidylate synthase
Tegafur Thymidylate synthase, DNA synthesis pathways
Uracil
2002
Adalimumab TNF-α (tumor necrosis factor-alpha)
Flox
Oxaliplatin
Pegfilgrastim G-CSF receptor
2004
Bevacizumab VEGF-A
Cetuximab EGFR
2006
Abx-egf EGFR
Lubiprostone ClC-2 chloride channels
Moviprep
Panitumumab EGFR
2008
Levoleucovori
Levoleucovorin Thymidylate synthase (indirect enhancement of 5-FU binding)
2010
Denosumab RANKL
Suprpep
Trisulfate
Ts-1 Thymidylate synthase, dihydropyrimidine dehydrogenase
2011
Rivaroxaba Factor Xa
Rivaroxaban Factor Xa
Vemurafenib BRAF V600E
2012
Aflibercept VEGF-A, VEGF-B
Regorafenib VEGFR1, VEGFR2
2014
Nivolumab PD-1
Pembrolizumab PD-1
Ramucirumab VEGFR-2
2015
Lde225 SMO (Smoothened protein)
Mm-398 Topoisomerase I
Naliri Topoisomerase I
Nalirifox Topoisomerase I, thymidylate synthase
Tas-102 DNA synthesis, thymidine phosphorylase
Tas102 DNA (via trifluridine incorporation), thymidine phosphorylase (tipiracil)
Tipiracil Thymidylate synthase, DNA polymerase
Trifluridine
Trifluridine-tipiracil Thymidine phosphorylase, DNA synthesis
2016
Atezolizumab PD-L1
Prasterone Estrogen receptors, androgen receptors
2017
Avelumab PD-L1
Bevacizumab-awwb VEGF-A
2018
Binimetinib MEK1, MEK2
Cemiplimab PD-1
Larotrectinib NTRK1, NTRK2
Ner1006
Plenvu
2019
Trastuzumab deruxtecan HER2
2020
Encorafenib BRAF V600E
Tucatinib HER2
2021
Dostarlimab PD-1
Sotorasib KRAS G12C
2022
Adagrasib KRAS G12C
Cp-675 CTLA-4
Tremelimumab CTLA-4
2023
Fruquintinib VEGFR-1, VEGFR-2
Retifanlimab PD-1
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