Drug Glossary

Complete database of oncology medications

2653
Total Drugs
29
Chemotherapy
119
Targeted Therapy
138
Immunotherapy

Treatment Regimens

Standard chemotherapy combinations for colorectal cancer

FOLFOX 3 Drugs · 1st line, Adjuvant FOLFIRI 3 Drugs · 1st line, 2nd line CAPOX/XELOX 2 Drugs · 1st line, Adjuvant FOLFOXIRI 4 Drugs · 1st line FOLFOX + Bev 4 Drugs · 1st line FOLFIRI + Bev 4 Drugs · 1st line, 2nd line FOLFIRI + Cetux 4 Drugs · 1st line, 2nd line FOLFIRI + Pani 4 Drugs · 1st line, 2nd line FOLFOXIRI + Bev 5 Drugs · 1st line Cape mono 1 Drugs · Adjuvant, Maintenance Pembro 1 Drugs · 1st line Enco + Cetux 2 Drugs · 2nd line+ T + P (HER2) 2 Drugs · 3rd line+ TAS-102 / Lonsurf 2 Drugs · 3rd line+
FDA Approval Timeline for CRC
1950
Radiotherapy DNA, cellular water molecules
1952
Leucovorin
1953
Methotrexate Dihydrofolate reductase
1955
Acetaminophen Cyclooxygenase enzymes (COX-1, COX-2)
Prednisone Glucocorticoid receptor
1956
Indocyanine green
1958
Dexamethasone Glucocorticoid receptor
Vancomycin oral capsule
1959
Cyclophosphamid
Cyclophosphamide
1960
Bisacodyl Enteric nervous system receptors
Fleet
1961
Nsaid COX-1, COX-2
1962
5-fluorouracil
Fluorouracil
1963
Bupivacaine Voltage-gated sodium channels
Gastrografin
1964
Melphala
Neomyci Bacterial 30S ribosomal subunit
1970
Floxuridine Thymidylate synthase
1971
Saline
1972
Bupivacain Voltage-gated sodium channels
1974
Doxorubicin DNA, Topoisomerase II
Mitomycin
1976
Loperamide Mu-opioid receptors
1978
Cisplatin
1985
Golytely
Midazolam GABA-A receptors
1986
Interferon Interferon receptors (IFNAR1/IFNAR2 for alpha interferon, IFNGR1/IFNGR2 for gamma interferon)
1989
Omeprazole H+/K+-ATPase proton pump
Propofol GABA-A receptors
1990
Glutamine
1991
Filgrastim G-CSF receptor (CSF3R)
G-csf G-CSF receptor
Ondansetro 5-HT3 receptors
Ondansetron 5-HT3 receptors
Sargramostim GM-CSF receptor
1992
Aldesleukin IL-2 receptor
Desflurane GABA-A receptors, NMDA receptors
Paclitaxel
1993
Enoxaparin Factor Xa, Factor IIa (thrombin)
1995
Sevoflurane GABA receptors, glycine receptors
1996
Docetaxel β-tubulin, microtubules
Gemcitabine DNA synthesis, ribonucleotide reductase
Irinotecan Topoisomerase I
Ropivacaine Voltage-gated sodium channels
1998
Capecitabine
Infliximab TNF-α
1999
Dexmedetomidine Alpha-2 adrenergic receptors
2000
Tinzapari Antithrombin III, Factor Xa
Tinzaparin Factor Xa, Thrombin
2001
Tegafu Thymidylate synthase
Tegafur Thymidylate synthase, DNA synthesis pathways
Uracil
Xeloda thymidylate synthase (TS)
2002
Adalimumab TNF-α (tumor necrosis factor-alpha)
Flox
Oxaliplatin
Pegfilgrastim G-CSF receptor
2004
Bevacizumab VEGF-A
Cetuximab EGFR
Us-erbitux® EGFR
Xelox chemotherapy DNA (crosslinking), Thymidylate Synthase (TYMS)
2006
Abx-egf EGFR
Lubiprostone ClC-2 chloride channels
Moviprep
Panitumumab EGFR
2008
Levoleucovori
Levoleucovorin Thymidylate synthase (indirect enhancement of 5-FU binding)
2010
Denosumab RANKL
Suprpep
Trisulfate
Ts-1 Thymidylate synthase, dihydropyrimidine dehydrogenase
2011
Rivaroxaba Factor Xa
Rivaroxaban Factor Xa
Vemurafenib BRAF V600E
2012
Aflibercept VEGF-A, VEGF-B
Regorafenib VEGFR1, VEGFR2
Vegf trap VEGF-A, VEGF-B
Zaltrap® VEGF-A, VEGF-B
2014
Nivolumab PD-1
Pembrolizumab PD-1
Ramucirumab VEGFR-2
2015
Lde225 SMO (Smoothened protein)
Mm-398 Topoisomerase I
Naliri Topoisomerase I
Nalirifox Topoisomerase I, thymidylate synthase
Tas-102 DNA synthesis, thymidine phosphorylase
Tas102 DNA (via trifluridine incorporation), thymidine phosphorylase (tipiracil)
Tipiracil Thymidylate synthase, DNA polymerase
Tipiracil hydrochloride combination agent tas-102 Thymidine phosphorylase, DNA polymerase
Trifluridine
Trifluridine and tipiracil DNA (via thymidine incorporation), Thymidine phosphorylase
Trifluridine and tipiracil hydrochloride DNA (thymidine analogue incorporation), Thymidine phosphorylase
Trifluridine cures Thymidine phosphorylase, DNA
Trifluridine-tipiracil Thymidine phosphorylase, DNA synthesis
2016
Atezolizumab PD-L1
Prasterone Estrogen receptors, androgen receptors
2017
Avelumab PD-L1
Bevacizumab-awwb VEGF-A
2018
Binimetinib MEK1, MEK2
Cemiplimab PD-1
Larotrectinib NTRK1, NTRK2
Ner1006
Plenvu
2019
Trastuzumab deruxtecan HER2
2020
Encorafenib BRAF V600E
Tucatinib HER2
2021
Dostarlimab PD-1
Sotorasib KRAS G12C
2022
Adagrasib KRAS G12C
Cp-675 CTLA-4
Tremelimumab CTLA-4
2023
Fruquintinib VEGFR-1, VEGFR-2
Retifanlimab PD-1
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