Ts-1 drug page Clinical trials

Trials with Ts-1

Every colorectal cancer trial that includes this drug. Those looking for patients come first.

4Trials
0Recruiting
2Countries
839Planned patients

Showing 1–4 of 4

A Study of Neoadjuvant Chemoradiotherapy With 5-FU/Leucovorin (FL) vs. TS-1/Irinotecan in Patients With Locally Advanced Rectal Cancer
Finished Phase 2 136 patients NCT01269216

This is an open-label, randomized phase II study. Patients will be randomly assigned to either FL or TS-1/irinotecan preoperative chemotherapy regimens by stratification. Patients in FL group will be treated with bolus injections of 5-FU 4…

South Korea Oct 2008 – Sept 2014 Interventional
Combined with: IrinotecanLeucovorin
A Phase I/II Trial of TS-1 and Oxaliplatin in Patients With Advanced Colorectal Cancer
Finished Phase 1 77 patients NCT00531245

Capecitabine and oxaliplatin(XELOX) is active first-line therapy for patients with metastatic colorectal cancer. Phase II study of TS-1, a novel oral fluoropyrimidine derivative, showed activity in patients with metastatic colorectal carci…

South Korea Aug 2006 – Mar 2009 Interventional
Combined with: Oxaliplatin
IRIS Followed by mFOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer
Finished Phase 3 200 patients NCT00316745

This randomized phase III study compares safety and efficacy of two sequence arms in advanced colorectal cancer: irinotecan and S-1 (IRIS) followed by oxaliplatin containing regimen (arm A), or l-leucovorin (l-LV), 5-FU and oxaliplatin (mF…

Japan Apr 2006 – Mar 2009 Interventional
Phase II/III Trial of CPT-11/5-FU/l-LV Versus CPT-11/TS-1 as Second Line Chemotherapy of Unresectable Colorectal Cancer
Finished Phase 2 426 patients NCT00284258

This study is designed as Phase II/III. Phase II is aimed to evaluate safety and efficacy of IRIS, and feasibility of FOLFIRI. Phase III is aimed to verify inferiority of the progression free survival of IRIS in comparison with FOLFIRI.

Japan Jan 2006 – Aug 2010 Interventional
Combined with: IrinotecanLeucovorin