Axitinib drug page Clinical trials

Trials with Axitinib

Every colorectal cancer trial that includes this drug. Those looking for patients come first.

8Trials
1Recruiting
9Countries
711Planned patients

Showing 1–8 of 8

Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial
Recruiting Phase 1 111 patients NCT04693468

This phase Ib trial is to find out the best dose, possible benefits and/or side effects of talazoparib when given in combination with palbociclib, axitinib, or crizotinib in treating patients with solid tumors that has spread to nearby tis…

United States Dec 2020 – Dec 2027 Interventional
Combined with: Crizotinib
TACE Plus Axitinib and Hydroxychlorquine for Liver-Dominant Metastatic Colorectal Cancer (CRC)
Finished Phase 1 5 patients NCT04873895

Liver metastases are a leading cause of death among patients with metastatic colorectal cancer. Duration of disease control is short following 2nd-line or later systemic therapy. Liver-directed therapy such as TACE has a higher response ra…

United States Jan 2022 – Apr 2024 Interventional
Combined with: Hydroxychloroquine
Study of PF-07265807 in Participants With Metastatic Solid Tumors.
Finished Phase 1 88 patients NCT04458259

A First-in-Human Pharmacokinetic, Safety, and Tolerability Study of PF-07265807 as Monotherapy and in Combination in Participants with Advanced or Metastatic Solid Tumors

United States, Canada, Italy, Japan and 1 more Sept 2020 – Nov 2024 Interventional
Combined with: PF-07265807Sasanlimab
Axitinib Monotherapy With Early Dynamic Contrast Enhanced Ultrasound Monitoring in Chemorefractory Third Line Metastatic Colorectal Cancer
Finished Phase 2 52 patients NCT04355156

This is a study of Axitinib versus placebo as monotherapy for people with colorectal cancer who have liver metastases and who have relapsed within 6 months of their last chemotherapy regime. The research will also look at the potential of …

United Kingdom Sept 2012 – Feb 2019 Interventional
A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC)
Finished Phase 2 70 patients NCT01490866

This is a non-randomized, open-label, Phase II trial investigating axitinib as a single-agent maintenance therapy following standard first-line FOLFOX/bevacizumab therapy for patients with mCRC.

United States Jan 2012 – Jul 2015 Interventional
Assessment of Tumor Vascular Effects of Axitinib With Dynamic Ultrasonography in Patients With Metastatic Colorectal Cancer
Finished 27 patients NCT01486251

The purpose of this study is to evaluate and quantify the dynamic modifications of tumor blood perfusion on axitinib therapy in patients with refractory mCRC for each dose of Axitinib.

France Sept 2011 – Sept 2014 Interventional
A Study Combining FOLFOX or FOLFIRI With AG-013736 or Bevacizumab (Avastin) in Patients With Metastatic Colorectal Cancer After Failure Of One First Line Regimen
Finished Phase 2 171 patients NCT00615056

The study is designed to demonstrate that the combination of AG-013736 with either FOLFIRI or FOLFOX is superior to FOLFIRI or FOLFOX in combination with bevacizumab (Avastin) in delaying tumor progression in the second-line treatment of p…

United States, Canada, France, Italy and 4 more Mar 2008 – Apr 2012 Interventional
Study With AG-013736 Combined With Chemotherapy And Bevacizumab In Patients With Metastatic Colorectal Cancer
Finished Phase 1 187 patients NCT00460603

To determine the safety and efficacy of AG-013736 in combination with other standard of care medication in patients with first line metastatic colorectal cancer.

United States Jan 2006 – Nov 2012 Interventional
Combined with: AG-013726Bevacizumab

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