Apatinib drug page Clinical trials

Trials with Apatinib

Every colorectal cancer trial that includes this drug. Those looking for patients come first.

5Trials
0Recruiting
1Countries
264Planned patients
All 5 Ongoing, not recruiting 1 Finished 4
Phase All Phase 2 4 Phase 3 1

Showing 1–5 of 5

Long-Course Concurrent Chemoradiotherapy With Adebrelimab and Apatinib as Neoadjuvant Therapy for Locally Advanced/Low-Lying Rectal Cancer Requiring Sphincter Preservation
Ongoing, not recruiting Phase 2 43 patients NCT07687433

To observe and evaluate the efficacy and safety of neoadjuvant long-course concurrent chemoradiotherapy combined with Adebrelimab and Apatinib Mesylate in the treatment of locally advanced rectal cancer and low-lying rectal cancer with sph…

China May 2026 – May 2029 Interventional
Combined with: Adebrelimab
See the trial ClinicalTrials.gov Am I eligible?
Neoadjuvant Therapy for Locally Advanced Colon Cancer
Finished Phase 2 64 patients NCT04625803

To determine the Efficacy and Safety of camrelizumab and apatinib combined with chemotherapy (mFOLFOX6) for MSS/pMMR locally advanced colon cancer.

China Jan 2021 – Sept 2023 Interventional
Combined with: Camrelizumab
See the trial ClinicalTrials.gov Am I eligible?
mFOLFOX6 Chemotherapy With Apatinib as Postoperative Treatment in Stage IIIB or IIIC Colorectal Cancer
Finished Phase 3 63 patients NCT03365765

This study will focus on postoperative patients of stage IIIB or stage IIIC colorectal cancer. These patients will start to accept chemotherapy in 3-4 weeks after operation, these patients were randomly divided into two groups, one group w…

China Feb 2018 – Dec 2022 Interventional
Combined with: 5-FluorouracilOxaliplatin
See the trial ClinicalTrials.gov Am I eligible?
Apatinib in Refractory Colorectal Cancer
Finished Phase 2 54 patients NCT03190616

Limited agents have been approved after standard first and second line treatment. Regorafenib and Trifluridine/Tipiracil (TAS-102) are still not approved in China.Apatinib has shown significant efficacy in refractory advanced gastric cance…

China Jul 2017 – Dec 2019 Interventional
See the trial ClinicalTrials.gov Am I eligible?
Dose Finding and Pharmacokinetics/Pharmacodynamics Study of Apatinib in the Treatment of Advanced Colorectal Cancer
Finished Phase 2 40 patients NCT01531777

RATIONALE: Apatinib is a tyrosin-inhibitor agent targeting at vascular endothelial growth factor receptor (VEGFR), and it's anti-angiogenesis effect has been viewed in preclinical tests. The investigators' phase I study has shown that the…

China Apr 2011 – Nov 2014 Interventional
See the trial ClinicalTrials.gov Am I eligible?