Afatinib drug page Clinical trials

Trials with Afatinib

Every colorectal cancer trial that includes this drug. Those looking for patients come first.

6Trials
1Recruiting
13Countries
8.038Planned patients

Showing 1–6 of 6

Pemigatinib + Afatinib in Advanced Refractory Solid Tumors
Recruiting Phase 1 70 patients NCT06302621

This study is researching whether the combination of Afatinib and Pemigatinib is safe and effective in FGFR altered unresectable or metastatic advanced solid tumors. The study is also trying to discover the highest doses of the study drug…

United States Apr 2024 – Dec 2027 Interventional
Combined with: Pemigatinib
Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)
Ongoing, not recruiting Phase 1 610 patients NCT04185883

To evaluate the safety and tolerability of sotorasib administered in investigational regimens in adult participants with KRAS p.G12C mutant advanced solid tumors.

United States, Australia, Austria, Belgium and 6 more Dec 2019 – Dec 2027 Interventional
Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
Ongoing, not recruiting Phase 1 731 patients NCT03785249

This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.

United States, Puerto Rico Jan 2019 – Dec 2026 Interventional
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
Ongoing, not recruiting Phase 2 6.452 patients NCT02465060

This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first started to nearb…

United States, Guam, Puerto Rico Aug 2015 – Dec 2026 Interventional
Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations
Finished Phase 2 100 patients NCT02795156

With the increased availability of next-generation sequencing, oncologists are starting to incorporate genomic profiling into routine care of cancer patients. If a genomic alteration is identified during profiling, it could help guide the …

United States Sept 2016 – Aug 2022 Interventional
Combined with: CabozantinibRegorafenib
Dual Targeting of EGFR With Cetuximab and Afatinib to Treat Refractory wtKRAS Metastatic Colorectal Cancer
Finished Phase 2 75 patients NCT01919879

This is a multicentric, phase II and open label study.75 patients are expected to be randomized in 35 centers. The main objective is to assess the efficacy and safety of Afatinib -cetuximab combo versus cetuximab alone in treatment of pati…

France Oct 2012 – Dec 2017 Interventional
Combined with: Cetuximab

Where the recruiting trials are