Lenvatinib drug page Clinical trials

Trials with Lenvatinib

Every colorectal cancer trial that includes this drug. Those looking for patients come first.

9Trials
1Recruiting
18Countries
1.405Planned patients

Showing 1–9 of 9

Lenvatinib Plus PD-1 Inhibitor for Advanced Solid Tumors With 11q13 Amplification
Recruiting Phase 2 60 patients NCT07417501

The goal of this clinical trial is to learn if the combination of lenvatinib and a PD-1 inhibitor (a type of immunotherapy) works to treat advanced solid tumors that have a specific genetic change called "11q13 amplification". It will also…

China Mar 2026 – Mar 2029 Interventional
Phase 2 Study of Pembrolizumab and Lenvatinib in Anal Squamous Cell Cancer
Not yet recruiting Phase 2 17 patients NCT07680088

The goal of this clinical trial is to see the safety and efficacy of pembrolizumab and lenvatinib in patients with anal squamous cell cancer that cannot be removed through surgery or is spread to other organs. Eligible participants should …

Sept 2026 – Sept 2030 Interventional
Combined with: Pembrolizumab
Gut Microbiota in Liver Cancer (Treated With TKIs In Combination With ICIs)
Ongoing, not recruiting Phase 2 70 patients NCT06563934

To evaluate the additional efficacy and safety of oral enterobacterial capsules in patients with intermediate and advanced liver cancer and treated with tyrosine kinase inhibitors (TKIs) combined with immunotherapy.

Aug 2024 – Nov 2026 Interventional
Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)
Ongoing, not recruiting Phase 1 105 patients NCT06462183

Phase 1 study to evaluate safety, tolerability and anti-tumor activity of RGT-61159 in patients with ACC or CRC

United States, Canada Aug 2024 – Dec 2027 Interventional
Combined with: RGT-61159
A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor
Ongoing, not recruiting Phase 1 301 patients NCT04008797

The primary objective of this study is to assess the safety and tolerability and to determine the recommended Phase 2 dose (RP2D) of E7386 in combination with other anticancer drug(s), and to determine the optimal dose of E7386 in combinat…

United States, Canada, China, Denmark and 6 more Jul 2019 – Mar 2027 Interventional
Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
Finished Phase 1 263 patients NCT05620134

This is a Phase 1/2, open-label, multi-center, first-in-human, dose escalation and cohort expansion study evaluating multiple doses and schedules of subcutaneously administered JK08 in patients with unresectable locally, advanced or metast…

Belgium, Spain Oct 2022 – Feb 2026 Interventional
Combined with: JK08Pembrolizumab
A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors
Finished Phase 1 89 patients NCT05091346

The Phase 1b part of this study is conducted to assess the safety and tolerability of E7386 in combination with pembrolizumab in participants with previously treated selected solid tumors, and to determine the recommended Phase 2 dose (RP2…

United States, Japan, Spain, United Kingdom Oct 2021 – Oct 2024 Interventional
Combined with: E7386Pembrolizumab
Study of Lenvatinib (MK-7902/E7080) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care in Participants With Metastatic Colorectal Cancer (MK-7902-017/E7080-G000-325/LEAP-017)
Finished Phase 3 480 patients NCT04776148

The purpose of this study is to assess the safety and efficacy of lenvatinib (MK-7902/E7080) in combination with pembrolizumab (MK-3475) in participants with metastatic colorectal cancer. The study will also compare lenvatinib plus pembrol…

United States, Argentina, Australia, Canada and 7 more Mar 2021 – Sept 2024 Interventional
Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma
Finished Phase 1 20 patients NCT02935309

This research study is designed to see if Capecitabine and Lenvatinib in combination with external radiation therapy are effective in treating locally advanced rectal adenocarcinoma in patients who have not yet had surgery, and what the be…

United States Oct 2016 – May 2020 Interventional
Combined with: Capecitabine

Where the recruiting trials are