Utomilumab (** Investigational drug (no approved brand names; also known as PF-05082566) **)

Immunotherapy

EU Experimental ES Not available 1 Clinical Trials

Description

Utomilumab is under investigation for the treatment of various cancers including colorectal cancer (CRC); it has shown promise in preclinical and early clinical studies by enhancing immune responses against tumors; however, its use in CRC is still experimental and no brand name has been approved yet.

Mechanism of Action

Utomilumab is a fully human IgG1 monoclonal antibody that binds to the CD137 receptor, also known as 4-1BB, which is expressed on activated T cells and NK cells; it acts by enhancing T cell proliferation and cytokine production, thereby amplifying immune responses.

Side Effects

Hypersensitivity reactions; gastrointestinal symptoms; fatigue; increased liver enzymes; infusion-related reactions

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT03290937 Phase 1
Completed
Utomilumab, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Metastatic Colorectal Cancer
United States