Rilotumumab (** Investigational drug (no approved brand names - development discontinued) **)

Immunotherapy

ES Not available 1 Clinical Trials

Description

Rilotumumab was investigated for its potential to inhibit tumor growth and progression in colorectal cancer by targeting PDGFRA. It has been studied primarily as a single agent or in combination with chemotherapy, but development was discontinued due to lack of efficacy compared to standard treatments.

Mechanism of Action

Rilotumumab is a recombinant humanized monoclonal antibody that binds to and inhibits the function of platelet-derived growth factor receptor alpha (PDGFRA), which is involved in angiogenesis and tumor cell proliferation.

Side Effects

Fatigue; nausea; diarrhea; anemia; neutropenia; thrombocytopenia

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT00788957 Phase 1
Archived
Panitumumab Combination Study With Rilotumumab or Ganitumab in Wild-type Kirsten Rat Sarcoma Virus Oncogene Homolog (KRAS) Metastatic Colorectal Cancer (mCRC)