Adavosertib

Clinical Trials Overview

1 trials found
About Adavosertib

Adavosertib is an investigational drug being studied in clinical trials for certain types of advanced cancers, including colorectal cancer. It is being investigated as a potential treatment option, particularly for tumors with specific genetic changes, like MET mutations. The drug is currently in Phase 2 trials, meaning it is being tested in a larger group of patients to see how well it works and what side effects it may cause. The goal of these trials is to determine if adavosertib can shrink tumors or slow their growth in patients whose cancer has not responded to other treatments. It is important to note that adavosertib is not yet approved for use in colorectal cancer and is only available as part of a clinical trial.

Category Other Medications
Brand Name ** Generic (investigational) **
Mechanism Adavosertib is a type of drug that targets specific proteins involved in cell signaling pathways that control cell growth and survival. Specifically, it targets the protein kinase known as 'Akt'. By inhibiting Akt, adavosertib aims to disrupt the signals that tell cancer cells to grow and divide, potentially leading to their death or slowing their proliferation. The specific molecular target is being characterized in clinical trials.
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Total Trials
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Recruiting
1
Active
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Completed
6,452
Total Enrollment
3
Countries
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
NCT02465060 Phase 2 Active 6,452 patients
Start: Aug 2015
End: Dec 2026
INTERVENTIONAL
Medications: Adavosertib Afatinib Binimetinib Capivasertib Copanlisib Crizotinib Dabrafenib Dasatinib Defactinib Erdafitinib Fexagratinib Ipatasertib Larotrectinib Nivolumab Osimertinib Palbociclib Pertuzumab Relatlimab Sapanisertib Taselisib Trametinib Trastuzumab Ulixertinib Vismodegib
This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first started to nearby tissue, l...
United States, Guam, Puerto Rico
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