TRK-950 (Not yet branded)

Other Medications

US Experimental EU Experimental ES Not available Oral 2 Clinical Trials
TRKA TRKB TRKC

Description

TRK-950 is a targeted therapy compound being developed for treatment of advanced solid tumors including colorectal cancer. Based on clinical trial data, this agent is designed for use in combination with other anti-cancer treatment regimens in patients with advanced malignancies. The drug appears to target specific molecular pathways across multiple tumor types, indicating a tumor-agnostic therapeutic approach.

Mechanism of Action

TRK-950 likely functions as a kinase inhibitor targeting the TRK (tropomyosin receptor kinase) family of proteins, which includes TRKA, TRKB, and TRKC receptors. These receptors are involved in cell growth, differentiation, and survival pathways, and when aberrantly activated through gene fusions or mutations, can drive tumor progression across various cancer types.

Molecular Targets

Side Effects

Fatigue Nausea Dizziness Peripheral neuropathy Constipation Decreased appetite Diarrhea Muscle weakness

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT03872947 Phase 1
Active, not recruiting
A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors
United States, France
NCT02990481 Phase 1
Archived
A Phase 1 Study Evaluating the Safety of TRK-950 in Patients With Advanced Solid Tumors
United States, France