Thymalfasin (Zadaxin)
Other Medications
Description
Thymalfasin is a synthetic immune modulator that enhances T-cell function and is being used in combination therapies for microsatellite stable (MSS) colorectal cancer. This immunomodulatory agent is particularly relevant for MSS/pMMR colorectal cancer patients who typically have poor responses to conventional checkpoint inhibitors alone. In colorectal cancer treatment, thymalfasin is combined with PD-1 inhibitors and standard chemoradiotherapy regimens to potentially overcome immune resistance in MSS tumors.
Mechanism of Action
Thymalfasin works by binding to and activating specific receptors on T-helper cells and dendritic cells, enhancing the maturation and function of T-lymphocytes. It promotes the production of interferon-gamma and interleukin-2, thereby augmenting the body's cellular immune response against cancer cells.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Zadaxin |
| Category | Other Medications |
 Status | Experimental |
 EMA Status | Not submitted to EMA |
 Spain Access | Not available |
| Administration | Subcutaneous |
| Clinical Trials | 3 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.