TC-510 (Not yet branded)

Other Medications

US Experimental EU Experimental ES Not available IV 1 Clinical Trials
Mesothelin

Description

TC-510 is an antibody-drug conjugate that targets mesothelin-expressing tumors, including colorectal cancer. This therapeutic combines a monoclonal antibody that specifically binds to mesothelin with a cytotoxic payload to deliver targeted chemotherapy directly to cancer cells. The drug is designed to treat advanced mesothelin-expressing cancers where mesothelin overexpression occurs.

Mechanism of Action

TC-510 works by binding to mesothelin, a glycoprotein that is overexpressed in various solid tumors including some colorectal cancers. Upon binding to mesothelin on the cancer cell surface, the antibody-drug conjugate is internalized, releasing its cytotoxic payload in

Molecular Targets

Side Effects

Fatigue Nausea Decreased appetite Infusion-related reactions Peripheral neuropathy Diarrhea Thrombocytopenia Neutropenia

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT05451849 Phase 1
Active, not recruiting
A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer
United States