RNK08954

Other Medications

Description

RNK08954 is an investigational medication currently being studied in clinical trials for various types of solid tumors, including colorectal cancer (CRC). It is being evaluated in combination with another investigational drug called IN10018. The trials are in Phase 1, which means they are primarily focused on determining the safety of the drug combination and finding the right dose. Some trials specifically include patients with CRC whose tumors have certain mutations, like KRAS G12D or EGFR mutations. The goal is to see if this combination therapy is safe and shows early signs of effectiveness in these patients. As it is in early-phase trials, the long-term benefits and risks are still being evaluated.

Mechanism of Action

RNK08954 is being studied in combination with IN10018. The specific way RNK08954 works (its mechanism of action) is not fully detailed in the available information, but it is being investigated as part of a combination therapy for solid tumors with specific genetic mutations, such as KRAS G12D. The trials aim to determine the recommended dose for further studies and evaluate its potential anti-tumor effects and safety profile when used with IN10018.

Side Effects

Since RNK08954 is an investigational drug in Phase 1 trials Detailed information about its specific side effects is still being gathered. The primary focus of Phase 1 trials is safety So researchers are carefully monitoring patients for any adverse events. More information about common and serious side effects will become available as the trials progress. The trial description mentions evaluating safety and pharmacokinetic characteristics.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT07441174 Phase 1
Recruiting
IN10018 in Combination With RNK08954 for the Treatment of KRASG12D Mutation-Positive Locally Advanced or Metastatic Solid Tumors
China
NCT06667544 Phase 1
Recruiting
A Study of RNK08954 in Subjects With Advanced Solid Tumors With KRAS ((Kirsten Rat Sarcoma) G12D Mutation
China