Resveratrol (Not yet branded)

Other Medications

US Experimental ES Not available Oral 2 Clinical Trials
SIRT1 NF-κB p53 cyclooxygenase enzymes

Description

Resveratrol is a natural polyphenolic compound found in grapes, berries, and red wine that is being evaluated as a potential adjuvant treatment for colorectal cancer. This phytochemical belongs to the stilbene class of compounds and has demonstrated anti-cancer properties in preclinical studies. In colorectal cancer, resveratrol is administered to patients with surgically resectable tumors to potentially enhance treatment outcomes through its multiple biological activities.

Mechanism of Action

Resveratrol exerts its anti-cancer effects through multiple molecular pathways, including activation of sirtuin proteins (particularly SIRT1), inhibition of nuclear factor-kappa B (NF- B) signaling, and modulation of apoptotic pathways. The compound also demonstrates anti-inflammatory and antioxidant properties that may help suppress tumor growth and metastasis. Additionally, resveratrol can induce cell cycle arrest and promote programmed cell death in cancer cells through p53-dependent mechanisms.

Molecular Targets

Side Effects

Gastrointestinal upset Nausea Diarrhea Headache Dizziness Fatigue Joint pain Skin rash

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT00433576 Phase 1
Archived
Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery
United States
NCT00256334 Phase 1
Archived
Resveratrol for Patients With Colon Cancer
United States