PRO95780 (Not yet branded)

Other Medications

US Experimental IV 2 Clinical Trials
Target not publicly disclosed

Description

PRO95780 is an experimental therapeutic agent being developed for colorectal cancer treatment in combination regimens. Based on clinical trial data, it is being evaluated alongside standard chemotherapy backbones including FOLFOX with bevacizumab for treatment-naive patients with locally advanced disease, and with cetuximab plus irinotecan or FOLFIRI plus bevacizumab for previously treated patients. The compound appears designed to enhance the efficacy of established CRC treatment combinations across different lines of therapy.

Mechanism of Action

The specific molecular mechanism of action for PRO95780 has not been publicly disclosed in available clinical documentation. Given its use in combination with both anti-EGFR therapy (cetuximab) and anti-VEGF therapy (bevacizumab) across different treatment settings, it likely targets a complementary pathway involved in colorectal cancer progression or resistance mechanisms.

Molecular Targets

Side Effects

Specific side effect profile not yet established Likely includes fatigue Nausea Diarrhea Neutropenia Peripheral neuropathy Skin reactions Hypertension Infusion reactions

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT00851136 Phase 1
Archived
A Study of PRO95780 Administered in Combination With the FOLFOX Regimen and Bevacizumab in Patients With Previously Untreated, Locally Advanced, Recurrent, and Metastatic Colorectal Cancer (APM4566g)
NCT00497497 Phase 1
Archived
A Study of PRO95780 in Combination With Cetuximab and Irinotecan Chemotherapy or the FOLFIRI Regimen With Bevacizumab in Patients With Previously Treated Metastatic Colorectal Cancer (APM4187g)