Prednisone (Deltasone, Rayos, Prednisone Intensol)
Other Medications · Approved since 1955
Description
Prednisone is a synthetic corticosteroid medication used in colorectal cancer treatment primarily as supportive care to manage immune-related adverse events, particularly severe colitis caused by immune checkpoint inhibitors. It serves as an anti-inflammatory and immunosuppressive agent to control treatment-related complications rather than directly treating the cancer itself. Prednisone may also be used as premedication to prevent allergic reactions to certain chemotherapy agents or to manage other inflammatory conditions that arise during cancer treatment.
Mechanism of Action
Prednisone acts as a glucocorticoid receptor agonist, binding to cytoplasmic glucocorticoid receptors and forming complexes that translocate to the nucleus to regulate gene transcription. This mechanism suppresses inflammatory cytokine production, reduces T-cell activation, and decreases immune system activity, making it effective for treating immune checkpoint inhibitor-induced colitis and other inflammatory complications of cancer therapy.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Deltasone, Rayos, Prednisone Intensol |
| Category | Other Medications |
 Status | FDA Approved |
 EMA Status | EMA Approved |
 Spain Access | Hospital use other indication |
| Administration | Oral |
| Year Approved | 1955 |
| Clinical Trials | 3 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.