PolyPEPI1018 (** Investigational drug (no commercial brand names available as it remains in clinical trials) **)

Other Medications

EU Experimental ES Not available 1 Clinical Trials

Description

PolyPEPI1018 is an investigational drug currently being studied in clinical trials for colorectal cancer (CRC). It is being tested in combination with another investigational drug called atezolizumab. This specific trial (NCT05243862) is a Phase 2 study looking at the safety, tolerability, and potential effectiveness of this combination. The trial is enrolling patients with microsatellite stable (MSS) CRC who have already tried multiple other treatments (progressed on 2 or 3 prior regimens). The goal is to see if this combination can help these patients, who have limited treatment options.

Mechanism of Action

PolyPEPI1018 is a type of vaccine designed to stimulate the body's immune system to recognize and attack cancer cells. It is being used in combination with atezolizumab, which is an immunotherapy drug that also helps the immune system fight cancer. The specific way PolyPEPI1018 works (the specific molecular target or mechanism) is still being investigated in clinical trials.

Side Effects

As PolyPEPI1018 is an investigational drug in early-phase trials The full range of potential side effects is still being evaluated. The trial is designed to monitor for safety and tolerability. Common side effects associated with vaccines can include reactions at the injection site (like pain Redness Swelling) Fever Chills Fatigue And muscle aches. Side effects related to atezolizumab (the drug it's combined with) can include fatigue Itching Diarrhea Nausea Loss of appetite And cough. The specific side effects observed in this trial are being carefully monitored and will be reported as the trial progresses.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT05243862 Phase 2
Active, not recruiting
Safety and Activity of PolyPEPI1018 Plus Atezolizumab in Colorectal Cancer.
United States

Quick Info

Brand Name** Investigational drug (no commercial brand names available as it remains in clinical trials) **
CategoryOther Medications
EU EMA StatusExperimental
ES Spain AccessNot available
Clinical Trials1
View Clinical Trials Back to Drug Glossary

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.