PF-07220060 (Not yet branded)

Other Medications

Experimental

Not available IV 3 Clinical Trials

Target not publicly disclosed

Description

PF-07220060 is a compound developed by Pfizer that has been evaluated in Phase 2 clinical trials for advanced solid tumors, including colorectal cancer. Based on its development pattern and trial design, this agent appears to be a targeted therapy designed for patients with specific molecular characteristics across multiple tumor types. The drug has been tested in tumor-agnostic studies, suggesting it targets a molecular pathway present across different cancer types rather than being specific to colorectal cancer alone.

Mechanism of Action

The specific molecular mechanism of action for PF-07220060 has not been publicly disclosed in detail by Pfizer. Given its tumor-agnostic development approach and Phase 2 trial design, it likely targets a fundamental cellular pathway or protein involved in cancer cell growth, survival, or DNA repair that is relevant across multiple solid tumor types.

Molecular Targets

Target not publicly disclosed

Side Effects

Specific side effect profile not publicly disclosed Fatigue Nausea Decreased appetite Diarrhea Headache Rash Laboratory abnormalities

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT05216432 Phase 1

Recruiting

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast

United States, Australia, France, Italy, Spain

NCT04606446 Phase 2

Recruiting

Study of PF-07248144 in Advanced or Metastatic Solid Tumors

United States, Australia, China, Japan, South Korea

NCT04557449 Phase 2

Active, not recruiting

Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors

United States, Argentina, China, Czechia, Japan, Mexico, Slovakia, United Kingdo

Quick Info

Brand Name	Not yet branded
Category	Other Medications
Status	Experimental
EMA Status	Experimental
Spain Access	Not available
Administration	IV
Clinical Trials	3

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.