PDS01ADC (Not yet branded)

Other Medications

US Experimental EU Experimental ES Not available IV 2 Clinical Trials
Specific target antigen not publicly disclosed

Description

PDS01ADC is an antibody-drug conjugate (ADC) being developed for treatment of metastatic colorecral cancer, particularly in patients with microsatellite stable (MSS) tumors. This compound combines a targeted antibody with a cytotoxic payload to deliver chemotherapy directly to cancer cells. The drug is being evaluated in combination with hepatic artery infusion pump therapy and systemic treatments for liver-predominant metastatic disease.

Mechanism of Action

As an antibody-drug conjugate, PDS01ADC consists of a monoclonal antibody linked to a cytotoxic drug that binds to specific antigens expressed on colorectal cancer cells. Once the antibody binds to its target on the tumor cell surface, the entire complex is internalized, allowing the cytotoxic payload to be released in

Molecular Targets

Side Effects

Fatigue Nausea Diarrhea Decreased appetite Peripheral neuropathy Neutropenia Thrombocytopenia Elevated liver enzymes

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT05286814 Phase 2
Recruiting
PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma
United States
NCT04708470 Phase 1
Active, not recruiting
A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers
United States