Paroxetine

Other Medications

Description

Paroxetine is an antidepressant medication. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). It is primarily used to treat depression, anxiety disorders, obsessive-compulsive disorder, panic disorder, and post-traumatic stress disorder. While not a standard treatment for colorectal cancer itself, it is being studied in clinical trials in combination with other investigational treatments for certain advanced cancers, including colorectal cancer. The purpose of these trials is to evaluate the safety and potential effectiveness of these combinations.

Mechanism of Action

Paroxetine works by increasing the levels of serotonin, a natural substance in the brain that helps maintain mental balance. It does this by preventing serotonin from being reabsorbed (reuptaken) by nerve cells, making more serotonin available to transmit signals between nerve cells. Its role in the context of cancer treatment being studied is not fully established and is part of the ongoing clinical investigation.

Side Effects

Common side effects of paroxetine can include nausea Drowsiness Dizziness Insomnia Dry mouth Constipation Sweating And sexual dysfunction. As it is being studied in combination with other investigational drugs for cancer The specific side effects observed in these trials may be different or more severe. Side effects are still being evaluated in ongoing trials.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT07070232 Phase 1
Recruiting
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
United States, Australia, Belgium, Germany, Italy, Spain, Turkey (Türkiye), Unit