Description
O6-Benzylguanine is an investigational drug used in combination with alkylating agents to overcome DNA repair mechanisms that confer resistance, particularly relevant in certain brain tumors. Its use in colorectal cancer remains experimental and lacks clinical validation.
Mechanism of Action
O6-Benzylguanine acts as a prodrug that alkylates the O6-position of guanine in DNA, thereby enhancing the cytotoxicity of certain chemotherapeutic agents like temozolomide by overcoming resistance mechanisms such as O6-methylguanine-DNA methyltransferase (MGMT) activity.
Side Effects
Neutropenia; anemia; thrombocytopenia; nausea; vomiting
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
NCT00005981
Phase 2
Archived
Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
United States