NGM438 (Not yet branded)

Other Medications

US Experimental EU Experimental ES Not available IV 2 Clinical Trials
Not yet disclosed

Description

NGM438 is a novel therapeutic compound currently in early-phase clinical development for advanced or metastatic solid tumors, including colorectal cancer. This agent is being evaluated both as a single agent and in combination with the PD-1 inhibitor pembrolizumab for patients with treatment-refractory malignancies. NGM438 represents part of NGM Biopharmaceuticals' pipeline targeting specific molecular pathways in cancer progression.

Mechanism of Action

The precise molecular mechanism of action for NGM438 has not been fully disclosed in public documentation. Based on NGM Biopharmaceuticals' focus on growth factor and metabolic pathway modulation, NGM438 likely targets key signaling cascades involved in tumor growth, metastasis, or the tumor microenvironment.

Molecular Targets

Side Effects

Specific side effect profile not yet established Fatigue Nausea Decreased appetite Skin reactions Gastrointestinal disturbances Potential infusion-related reactions Laboratory abnormalities

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT05311618 Phase 1
Unknown
Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors
United States
NCT05215574 Phase 1
Active, not recruiting
Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
United States