Muzastotug (Not yet branded)

Other Medications

US Experimental IV 1 Clinical Trials
Unknown specific targets

Description

Muzastotug is an experimental compound being evaluated in early-phase clinical trials for microsatellite stable (MSS) colorectal cancer. Based on the available trial data, it is being tested in combination with established therapies including leucovorin, fluorouracil, and FOLFIRI regimens, suggesting it may serve as an adjunct to standard chemotherapy protocols. The drug appears to be specifically targeted toward MSS tumors, which typically have limited response to immunotherapy approaches.

Mechanism of Action

The specific molecular mechanism of action for Muzastotug has not been fully disclosed in publicly available trial information. Given its use in combination with chemotherapy regimens and focus on MSS colorectal cancers, it likely targets pathways involved in tumor growth or immune response modulation specific to microsatellite stable disease.

Molecular Targets

Side Effects

Specific side effect profile not yet established from early-phase trials Fatigue Nausea Decreased appetite Diarrhea Infusion-related reactions Elevated liver enzymes Low white blood cell count

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT07363408 med_phase_prefix1
Not yet recruiting
Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer
United States