Mangafodipir (Teslascan (discontinued), PledOx)
Other Medications
Description
Mangafodipir is a manganese-based contrast agent that serves as a neuroprotective compound in colorectal cancer treatment. It is specifically used as an adjunctive therapy to prevent oxaliplatin-induced peripheral neuropathy (OXAIPN) in patients receiving FOLFOX chemotherapy regimens. The drug functions as a selective antioxidant that protects normal tissues from chemotherapy-induced oxidative damage while preserving the anti-tumor efficacy of oxaliplatin-based treatments.
Mechanism of Action
Mangafodipir acts as a superoxide dismutase mimetic, catalyzing the dismutation of superoxide radicals to hydrogen peroxide and oxygen. The compound selectively accumulates in normal tissues rather than tumor cells, providing protective antioxidant activity against oxaliplatin-induced neurotoxicity without interfering with the platinum agent's cytotoxic effects on cancer cells.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Teslascan (discontinued), PledOx |
| Category | Other Medications |
 Status | Experimental |
| Administration | IV |
| Clinical Trials | 3 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.