Loperamide (Imodium, Imodium A-D, Kaopectate II)
Other Medications · Approved since 1976
Description
Loperamide is an opioid receptor agonist antidiarrheal medication used as supportive care in colorectal cancer patients to manage treatment-related diarrhea. It is commonly prescribed to control diarrhea caused by chemotherapy, targeted therapies, or immunotherapy-induced colitis. Loperamide helps maintain patient quality of life and allows continuation of cancer treatment by effectively managing gastrointestinal side effects.
Mechanism of Action
Loperamide binds to mu-opioid receptors in the intestinal wall, slowing intestinal motility and increasing water and electrolyte absorption from the bowel. This mechanism reduces stool frequency and improves stool consistency without significant central nervous system effects due to poor blood-brain barrier penetration.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Imodium, Imodium A-D, Kaopectate II |
| Category | Other Medications |
 Status | FDA Approved |
| Administration | Oral |
| Year Approved | 1976 |
| Clinical Trials | 2 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.