lidocaine (Xylocaine, Lignocaine)
Other Medications
Description
Lidocaine is a local anesthetic and antiarrhythmic agent from the amide class that is used perioperatively in colorectal cancer surgery to improve postoperative outcomes. In CRC treatment, lidocaine is administered as a continuous intravenous infusion during and after surgical resection to reduce postoperative pain, decrease opioid requirements, and potentially improve long-term survival outcomes. The drug serves as an adjunctive perioperative intervention rather than a direct anticancer therapy, with clinical evidence suggesting benefits for immune function preservation and enhanced recovery after colorectal surgery.
Mechanism of Action
Lidocaine blocks voltage-gated sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses to provide analgesic effects. Beyond its anesthetic properties, lidocaine exhibits anti-inflammatory effects by reducing cytokine release and may help preserve immune function during the perioperative period, which could potentially impact long-term cancer outcomes.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Xylocaine, Lignocaine |
| Category | Other Medications |
 Status | Off-label |
 EMA Status | EMA Approved |
 Spain Access | Hospital use other indication |
| Administration | IV |
| Clinical Trials | 11 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.