Lgk974

Other Medications

EU Not submitted to EMA ES Not available 1 Clinical Trials

Description

LGK974 is an investigational drug that has been studied in clinical trials for certain types of cancer. It is currently not approved for treating colorectal cancer. In clinical trials, LGK974 was studied in patients whose cancers might depend on signals from a pathway called Wnt. One trial specifically looked at LGK974 in patients with BRAF V600 mutations. The trials were early-phase (Phase 1), meaning they primarily focused on determining the safety and appropriate dosage of the drug, rather than its effectiveness. LGK974 was tested alone and in combination with another investigational drug called PDR001.

Mechanism of Action

LGK974 is being investigated as a potential treatment for cancers that rely on the Wnt signaling pathway for growth. The Wnt pathway is a series of steps inside cells that control many functions, including cell growth and division. LGK974 is designed to interfere with this pathway. The specific way LGK974 interacts with the Wnt pathway is being studied, but it is intended to block signals that promote cancer cell growth.

Side Effects

As LGK974 is an investigational drug in early-phase trials Comprehensive information on side effects is still being gathered. The primary focus of Phase 1 trials is safety. Specific side effects observed in the NCT01351103 trial are not detailed in the provided information. However Like many cancer drugs LGK974 may cause side effects. Patients participating in clinical trials are closely monitored for any adverse events.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT01351103 Phase 1
Completed
A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands
United States, Canada, France, Germany, Italy, Netherlands, Spain

Quick Info

CategoryOther Medications
EU EMA StatusNot submitted to EMA
ES Spain AccessNot available
Clinical Trials1
View Clinical Trials Back to Drug Glossary

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.