Description
Lewis-Y is a carbohydrate antigen that serves as a target for immunotherapy approaches in colorectal cancer treatment. This antigen is overexpressed on many colorectal cancer cells, making it a suitable target for antibody-based therapeutic strategies.
Mechanism of Action
Anti-Lewis-Y antibodies bind specifically to Lewis-Y antigens expressed on cancer cell surfaces, triggering immune-mediated destruction of tumor cells through antibody-dependent cellular cytotoxicity and complement activation.
Side Effects
Infusion reactions
Fatigue
Nausea
Fever
Chills
Headache
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
NCT04842812
med_phase_prefix1
Recruiting
Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors
China