Leukovorin (** - Generic: Leucovorin calcium - Brand names: Wellcovorin, Folinic Acid **)
Other Medications
Description
Leukovorin is used in combination with fluoropyrimidine agents such as 5-fluorouracil (5-FU) or capecitabine to enhance their efficacy by providing an active form of folate that the tumor cells can use; it is commonly used in first-line and second-line treatment regimens for colorectal cancer, particularly when combined with irinotecan or oxaliplatin.
Mechanism of Action
Leukovorin acts as a folinic acid prodrug that enhances the efficacy of methotrexate by providing an active form of folic acid, which is essential for DNA synthesis and repair; it also antagonizes the toxic effects of high-dose methotrexate.
Side Effects
Neutropenia; anemia; thrombocytopenia; nausea and vomiting; diarrhea; stomatitis; allergic reactions; interstitial pneumonitis
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
NCT00689624
Phase 2
Archived
Irinotecan/Oxaliplatin/5-Fluorouracil/Leucovorin/Cetuximab As First Line Treatment In Colorectal Cancer
Greece