Lederfolin (** Lederfolin (generic: leucovorin calcium/folinic acid) **)
Other Medications
Description
Lederfolin is used in combination with fluoropyrimidine agents such as 5-fluorouracil (5-FU) or capecitabine for the treatment of colorectal cancer. It improves the therapeutic index by reducing toxicity and enhancing antitumor activity, particularly when used in adjuvant settings or as part of first-line therapy.
Mechanism of Action
Lederfolin acts as a folate analog that enhances the efficacy of fluoropyrimidine-based chemotherapy by providing an alternative substrate for thymidylate synthase, thereby increasing DNA synthesis and repair in rapidly dividing cells.
Side Effects
Neutropenia; anemia; diarrea; náuseas; vómitos;
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
NCT05253846
Phase 2
Active, not recruiting
Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29
Italy