Description
Itraconazole is a triazole antifungal medication that has shown anticancer properties through its ability to inhibit multiple cellular pathways involved in tumor growth and progression. While primarily used to treat fungal infections, it demonstrates activity against cancer cells by targeting the Hedgehog signaling pathway and angiogenesis. The drug is being repurposed for oncological applications due to its anti-proliferative and anti-angiogenic effects.
Mechanism of Action
Itraconazole works by inhibiting the Hedgehog signaling pathway, which is crucial for cancer stem cell maintenance and tumor growth, while also blocking angiogenesis by interfering with VEGF receptor trafficking and cholesterol biosynthesis pathways that support blood vessel formation.
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.