Itraconazole (Sporanox, Onmel)

Other Medications

4 Clinical Trials

Description

Itraconazole is a triazole antifungal medication that has shown anticancer properties through its ability to inhibit multiple cellular pathways involved in tumor growth and progression. While primarily used to treat fungal infections, it demonstrates activity against cancer cells by targeting the Hedgehog signaling pathway and angiogenesis. The drug is being repurposed for oncological applications due to its anti-proliferative and anti-angiogenic effects.

Mechanism of Action

Itraconazole works by inhibiting the Hedgehog signaling pathway, which is crucial for cancer stem cell maintenance and tumor growth, while also blocking angiogenesis by interfering with VEGF receptor trafficking and cholesterol biosynthesis pathways that support blood vessel formation.

Side Effects

Nausea Vomiting Diarrhea Abdominal pain Headache Dizziness Elevated liver enzymes Hypokalemia Edema And potential cardiac toxicity with prolonged use

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT07070232 Phase 1
Recruiting
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
United States, Australia, Belgium, Germany, Italy, Spain, Turkey (Türkiye), Unit
NCT06400472 Phase 1
Recruiting
A Study of LY4170156 in Participants With Selected Advanced Solid Tumors
United States, Australia, France, Italy, Japan, South Korea, Spain
NCT05150691 Phase 1
Recruiting
A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
United States, Australia, China, Puerto Rico, South Korea, Taiwan
NCT06084481 Phase 1
Active, not recruiting
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
United States, Australia, Israel, Japan, Puerto Rico, South Korea, Spain, Taiwan

Quick Info

Brand NameSporanox, Onmel
CategoryOther Medications
Clinical Trials4
View Clinical Trials Back to Drug Glossary

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.