Isovorin (** - Fusilev (brand name) - Levoleucovorin (generic) **)
Other Medications
Description
Levoleucovorin is commonly used in combination with fluoropyrimidines like capecitabine or 5-fluorouracil (5-FU) for the treatment of metastatic colorectal cancer. It enhances the efficacy and reduces toxicity by modulating folate metabolism, which is crucial for DNA synthesis.
Mechanism of Action
Levoleucovorin acts as a rescue agent for methotrexate toxicity by enhancing the reduction of oxidized folates to their reduced form, which is essential for DNA synthesis and repair.
Side Effects
Neutropenia; anemia; leucopenia; trombocitopenia
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
NCT00316745
Phase 3
Suspended
IRIS Followed by mFOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer
Japan