Inulin (Not yet branded)

Other Medications

US Experimental EU Experimental ES med_spain_not_available Oral 1 Clinical Trials
Gut microbiome

Description

Inulin is a prebiotic fiber supplement being evaluated as a microbiome-modulating agent in metastatic colorectal cancer treatment. This soluble dietary fiber serves as a selective nutrient for beneficial gut bacteria and is being combined with immunotherapy and anti-angiogenic agents to potentially enhance treatment efficacy. Inulin acts as a gut microbiome modulator that may improve immune system function and treatment response in advanced colorectal cancer patients.

Mechanism of Action

Inulin functions as a prebiotic that selectively stimulates the growth and activity of beneficial bacteria in the colon, particularly bifidobacteria and lactobacilli. This microbiome modulation may enhance immune system function and potentially improve the efficacy of concurrent immunotherapy treatments. The mechanism involves fermentation by gut bacteria to produce short-chain fatty acids that can influence immune responses and tumor microenvironment.

Molecular Targets

Side Effects

Gastrointestinal bloating Flatulence Abdominal cramping Diarrhea Nausea Changes in bowel movements Mild stomach discomfort

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT06347198 Early med_phase_prefix1
Unknown
Oral Inulin in Combination With Fruquintinib Plus Sintilimab as Third- or Further-line Treatment in Metastatic Colorectal Cancer
China