GTI-2040

Other Medications

1 Clinical Trials

Description

GTI-2040 is an experimental drug that has been studied in clinical trials for certain types of cancer, including colorectal cancer. It was investigated by the National Cancer Institute (NCI) in a Phase 1 trial, primarily to determine the highest safe dose when given in combination with standard chemotherapy drugs capecitabine and oxaliplatin. This trial focused on patients with advanced colorectal cancer or other solid tumors. The goal was to see how patients tolerated the combination and to understand how the drugs interact within the body. GTI-2040 is not currently an approved treatment for colorectal cancer.

Mechanism of Action

GTI-2040 is designed to target ribonucleotide reductase (RR), an enzyme crucial for DNA synthesis and repair in rapidly dividing cells, like cancer cells. By inhibiting RR, GTI-2040 aims to reduce the availability of building blocks needed for DNA replication, potentially slowing or stopping cancer cell growth. The trial specifically looked at changes in dCTP levels (a component of DNA) and RR-M2 mRNA levels as markers of RR inhibition.

Side Effects

As GTI-2040 is an investigational drug studied in a Phase 1 trial Specific side effect data is limited and primarily focused on safety and determining the maximum tolerated dose in combination with other chemotherapy agents. The trial description mentions the study of toxicities at each dose level. Common side effects associated with the chemotherapy drugs used in combination (capecitabine and oxaliplatin) include nausea Vomiting Diarrhea Fatigue Hand-foot syndrome And neuropathy. The specific side effects related to GTI-2040 itself are still being evaluated in ongoing or future studies.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT00084643 Phase 1
Completed
GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors
United States

Quick Info

CategoryOther Medications
Clinical Trials1
View Clinical Trials Back to Drug Glossary

Related Medications

Uracil
Other Medications
786 trials
Leucovorin
Other Medications
647 trials
Paclitaxel
Other Medications
54 trials
Trifluridine
Other Medications
50 trials
Cyclophosphamid
Other Medications
50 trials
Cyclophosphamide
Other Medications
49 trials

Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.