Glutamine (Enterex, NutriStore, various generic formulations)
Other Medications · Approved since 1990
Description
Glutamine is a conditionally essential amino acid used as a supportive care medication in colorectal cancer treatment to prevent and manage chemotherapy-induced toxicities. It serves as a cytoprotective agent specifically employed to reduce oxaliplatin-induced peripheral neuropathy and irinotecan-induced severe diarrhea. Glutamine supplementation helps maintain intestinal barrier function and supports the repair of chemotherapy-damaged tissues, particularly the gastrointestinal mucosa and peripheral nerves.
Mechanism of Action
Glutamine functions as the primary fuel source for rapidly dividing cells, including intestinal epithelial cells and immune cells, supporting cellular metabolism and protein synthesis during periods of metabolic stress. It serves as a precursor for glutathione synthesis, enhancing antioxidant defenses that protect against chemotherapy-induced oxidative damage to normal tissues. Additionally, glutamine maintains intestinal barrier integrity by supporting tight junction proteins and promoting mucosal healing.
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Enterex, NutriStore, various generic formulations |
| Category | Other Medications |
 Status | FDA Approved |
| Administration | Oral |
| Year Approved | 1990 |
| Clinical Trials | 2 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.