GI-102

Other Medications

EU Not submitted to EMA ES Not available 1 Clinical Trials

Description

GI-102 is an experimental medicine currently being studied in clinical trials for various advanced solid tumors, including colorectal cancer. It is being investigated to see if it is safe and effective. GI-102 is a bi-specific Fc fusion protein, meaning it's designed to interact with two different targets in the body. It is being tested both by itself and in combination with other cancer treatments like bevacizumab, pembrolizumab, doxorubicin, eribulin, paclitaxel, and trastuzumab deruxtecan. The trials are in early phases (Phase 1), meaning researchers are primarily looking at safety and determining the right dose. It is not yet approved for treating colorectal cancer or any other condition.

Mechanism of Action

GI-102 is a novel bi-specific protein. One part of the protein (CD80) targets tumor cells and certain immune cells (Treg cells). The other part (IL-2 variant) is designed to stimulate the activity of other immune cells, like NK cells and CD8 T cells, which can help fight cancer. The specific molecular targets and the exact way GI-102 works are still being characterized in clinical trials.

Side Effects

Because GI-102 is still in early-phase clinical trials (Phase 1) The full range of potential side effects is still being evaluated. Information about side effects from these trials is not yet widely available. Researchers are carefully monitoring patients in the trials to assess safety and identify any adverse events.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT05824975 Phase 1
Recruiting
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
United States, South Korea

Quick Info

CategoryOther Medications
EU EMA StatusNot submitted to EMA
ES Spain AccessNot available
Clinical Trials1
View Clinical Trials Back to Drug Glossary

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.