Fluorouracyl (** Adrucil, Carac, Efudex, Fluoroplex (Generic also available) **)
Other Medications
Description
Fluorouracil is a cornerstone of chemotherapy for colorectal cancer (CRC), commonly used in combination with leucovorin to enhance its efficacy. It is often employed as first-line therapy and can be part of adjuvant treatment after surgery or as palliative care for advanced disease.
Mechanism of Action
Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase, an enzyme essential for DNA synthesis and repair in rapidly dividing cells.
Side Effects
Bone marrow suppression; mucositis; nausea and vomiting; diarrhea; fatigue; hand-foot syndrome
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
NCT02842580
Phase 2
Archived
De-escalation Chemotherapies Versus Escalation in Non Pre-treated Unresectable Patients With Metastatic Colorectal Cancer
France