Ferumoxytol (Feraheme)

Other Medications · Approved since 2009

US Off-label EU Not submitted to EMA ES Not funded other indication IV 2 Clinical Trials

Description

Ferumoxytol is an ultrasmall superparamagnetic iron oxide nanoparticle that serves as both an iron replacement therapy and MRI contrast agent. In colorectal cancer, it is primarily used as an imaging enhancement tool to improve magnetic resonance imaging visualization of lymph nodes and tumor vasculature. The agent provides superior contrast enhancement compared to standard gadolinium-based agents, particularly for assessing lymph node involvement in locally advanced rectal cancer.

Mechanism of Action

Ferumoxytol nanoparticles are taken up by macrophages in the reticuloendothelial system, creating distinctive signal changes on T2-weighted MRI sequences. The iron oxide core causes local magnetic field disturbances that enhance contrast between normal and abnormal tissues, allowing for better delineation of lymph node architecture and tumor boundaries.

Side Effects

Hypotension Dizziness Nausea Headache Peripheral edema Diarrhea Constipation Injection site reactions

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT03280277 Early Phase 1
Archived
Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Locally Advanced Rectal Cancer
United States
NCT01770353 Phase 1
Archived
MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment
United States

Quick Info

Brand NameFeraheme
CategoryOther Medications
US StatusOff-label
EU EMA StatusNot submitted to EMA
ES Spain AccessNot funded other indication
AdministrationIV
Year Approved2009
Clinical Trials2
View Clinical Trials Back to Drug Glossary

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.