Etbx-011 (Not yet branded)

Other Medications

US Experimental EU Experimental ES med_spain_not_available Intramuscular 3 Clinical Trials
CEA (carcinoembryonic antigen)

Description

ETBX-011 is a recombinant adenovirus type 5 (Ad5) based cancer vaccine that targets carcinoembryonic antigen (CEA) expressing tumors. This immunotherapy agent is designed as a therapeutic vaccine for patients with CEA-positive colorectal cancer and other solid tumors. The vaccine uses a modified adenoviral vector (E1-, E2b- deleted) to deliver CEA(6D), a modified version of the CEA antigen, to stimulate anti-tumor immune responses.

Mechanism of Action

ETBX-011 works by using a replication-defective adenoviral vector to deliver the CEA(6D) antigen to antigen-presenting cells, particularly dendritic cells. This presentation stimulates both CD4+ and CD8+ T-cell responses against CEA-expressing tumor cells, generating targeted cytotoxic T-lymphocyte activity. The vaccine aims to break immune tolerance to the CEA self-antigen and create lasting immunological memory against CEA-positive cancer cells.

Molecular Targets

Side Effects

Injection site reactions Flu-like symptoms Fatigue Fever Chills Muscle aches Headache Nausea

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT03563157 med_phase_prefix1
Archived
QUILT 3.071: NANT Colorectal Cancer (CRC) Vaccine
United States
NCT03384316 med_phase_prefix1
Archived
Multi-Targeted Recombinant Ad5 (CEA/MUC1/Brachyury) Based Immunotherapy Vaccine Regimen in People With Advanced Cancer
United States
NCT03127098 med_phase_prefix1
Archived
QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803 (Super-agonist IL-15) in Subjects Having CEA-Expressing Cancer
United States

Quick Info

Brand NameNot yet branded
CategoryOther Medications
US StatusExperimental
EU Estado EMAExperimental
ES Acceso Españamed_spain_not_available
AdministrationIntramuscular
Clinical Trials3
View Clinical Trials Back to Drug Glossary

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.