Description
Dronabinol is a synthetic form of delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, used as supportive care in colorectal cancer patients. It is primarily prescribed to manage chemotherapy-induced nausea and vomiting, as well as to stimulate appetite in cancer patients experiencing significant weight loss.
Mechanism of Action
Dronabinol works by binding to cannabinoid receptors (CB1 and CB2) in the central nervous system and peripheral tissues, which helps suppress nausea and vomiting reflexes while stimulating appetite centers in the brain.
Side Effects
Dizziness
Drowsiness
Euphoria
Confusion
Dry mouth
Orthostatic hypotension
Tachycardia
Paranoia
Anxiety
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
NCT06731894
Phase 2
Recruiting
Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors
United States