Chemoradiotherapy (Not applicable (treatment regimen))
Other Medications
Description
Chemoradiotherapy is a combined treatment modality that delivers chemotherapy agents concurrently with radiation therapy for colorectal cancer, particularly in locally advanced rectal cancer. This approach serves as neoadjuvant therapy to downsize tumors prior to surgical resection and may enable organ preservation strategies. The combination enhances the radiosensitizing effects of chemotherapy agents, typically fluoropyrimidines like 5-fluorouracil or capecitabine, to improve local tumor control and potentially avoid the need for radical surgery.
Mechanism of Action
The chemotherapy agents act as radiosensitizers, enhancing the cytotoxic effects of ionizing radiation on cancer cells by inhibiting DNA repair mechanisms and increasing cellular sensitivity to radiation-induced damage. Fluoropyrimidines interfere with thymidine synthesis and DNA replication, while radiation causes direct DNA strand breaks and generates reactive oxygen species that damage cellular components.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | Not applicable (treatment regimen) |
| Category | Other Medications |
 Status | FDA Approved |
| Administration | IV, Oral |
| Clinical Trials | 3 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.