Cdx-1140

Other Medications

EU Experimental ES Not available 1 Clinical Trials

Description

CDX-1140 is an experimental medication currently being studied in clinical trials for various advanced cancers, including colorectal cancer. It is being investigated to see if it can help stimulate the body's immune system to fight cancer. In trials for colorectal cancer, CDX-1140 has been studied alone or in combination with other treatments like CDX-301, pembrolizumab (an immunotherapy drug), or chemotherapy. The trials are primarily focused on determining the safety and appropriate dosage of CDX-1140, as well as looking for early signs of effectiveness. It is not yet approved for use in colorectal cancer.

Mechanism of Action

CDX-1140 is designed to target CD40, a protein found on certain immune cells and some cancer cells. By activating CD40, CDX-1140 aims to boost the activity of the immune system, specifically T cells, to help them recognize and attack cancer cells. The specific way CDX-1140 interacts with CD40 and its precise effects on the immune response are still being studied in clinical trials.

Side Effects

As CDX-1140 is still in early-phase clinical trials (Phase 1) The full range of potential side effects is still being evaluated. Information from the NCT03329950 trial indicates that the study is designed to assess the safety and tolerability of CDX-1140. Patients enrolled in these trials are closely monitored for any adverse events. Specific side effects observed in these early trials are not detailed in the provided information But common side effects associated with drugs that stimulate the immune system can include flu-like symptoms Fatigue Rash And potential autoimmune reactions. More detailed side effect information will become available as trials progress.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT03329950 Phase 1
Archived
A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies
United States

Quick Info

CategoryOther Medications
EU EMA StatusExperimental
ES Spain AccessNot available
Clinical Trials1
View Clinical Trials Back to Drug Glossary

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.