Description
CDDP-50 is used in the treatment of colorectal cancer as part of combination chemotherapy regimens; however, its use has declined due to the advent of more targeted therapies. It may be employed in specific settings such as refractory or recurrent disease, particularly when combined with fluoropyrimidines like 5-FU.
Mechanism of Action
CDDP-50, also known as cisplatin, exerts its cytotoxic effects by binding to DNA and forming intrastrand cross-links, primarily with the purine bases, which inhibits DNA replication and transcription.
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.