Calmangafodipir (PledOx)
Other Medications
Description
Calmangafodipir is a manganese-based chelate compound that functions as a neuroprotective agent specifically used to prevent oxaliplatin-induced peripheral neuropathy in colorectal cancer patients. This supportive care medication is administered alongside oxaliplatin-based chemotherapy regimens to reduce the neurotoxic effects that commonly limit treatment duration and quality of life. Calmangafodipir works by protecting peripheral nerve cells from oxidative damage caused by platinum-based chemotherapy while preserving the anticancer efficacy of oxaliplatin.
Mechanism of Action
Calmangafodipir releases manganese ions in tissues, which act as cofactors for superoxide dismutase enzymes that neutralize reactive oxygen species and reduce oxidative stress in peripheral nerve cells. The compound selectively accumulates in normal tissues rather than tumor cells, providing neuroprotection without interfering with oxaliplatin's cytotoxic effects against cancer cells.
Molecular Targets
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.
Clinical Trials
Quick Info
| Brand Name | PledOx |
| Category | Other Medications |
 Status | Experimental |
 EMA Status | Not submitted to EMA |
 Spain Access | Not available other indication |
| Administration | IV |
| Clinical Trials | 2 |
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.