Ca102n (Not yet branded)

Other Medications

US Experimental EU Experimental ES Not available IV 2 Clinical Trials
EGFR

Description

CA102N is an EGFR-targeted therapeutic agent being developed for treatment of metastatic colorectal cancer, particularly in patients with relapsed or refractory disease. It has been evaluated both as monotherapy and in combination with trifluridine/tipiracil (TAS-102) for patients with advanced solid tumors including colorectal cancer. The drug is designed to target EGFR-expressing tumors and has shown potential for use in heavily pretreated metastatic colorectal cancer patients where standard therapies have failed.

Mechanism of Action

CA102N functions as an EGFR inhibitor, blocking the epidermal growth factor receptor pathway that is frequently dysregulated in colorectal cancer. By inhibiting EGFR signaling, the drug disrupts cellular proliferation, survival, and metastatic processes in cancer cells that depend on this pathway for growth.

Molecular Targets

Side Effects

Skin rash Diarrhea Fatigue Nausea Decreased appetite Acneiform dermatitis Dry skin Paronychia

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT06039202 Phase 2
Unknown
Phase 2 Study of CA102N Combined With TAS-102 Compared to Bevacizumab Combined With TAS-102 in Subjects With Relapsed and/or Refractory Metastatic Colorectal Cancer
NCT03616574 Phase 1
Archived
First-in-human Study of CA102N Monotherapy and CA102N Combined With Trifluridine/Tipiracil (LONSURF) in Subjects With Advanced Solid Tumors
United States