Atirmociclib

Other Medications

Description

Atirmociclib is an investigational drug currently being studied in clinical trials for certain types of cancer. In colorectal cancer (CRC) trials, it is being investigated in combination with other drugs. The trials are in early phases (Phase 1), meaning they primarily focus on determining the safety and appropriate dosage of the drug, often in patients who have not responded to standard treatments. The goal is to see if the combination is safe and if it shows any signs of effectiveness. It is being studied in patients with specific genetic mutations, such as HER2 or MET mutations, or KRAS wild-type tumors. Atirmociclib is not yet approved for treating CRC.

Mechanism of Action

Atirmociclib is a type of drug that targets specific proteins involved in cell growth and division. It belongs to a class of drugs called cyclin-dependent kinase (CDK) inhibitors. By inhibiting these CDKs, atirmociclib aims to stop or slow down the growth of cancer cells. The specific molecular target is being characterized in clinical trials.

Side Effects

As atirmociclib is an investigational drug in early-phase trials The full range of potential side effects is still being evaluated. Side effects observed in trials involving similar drugs (CDK inhibitors) or in the specific trials for atirmociclib (if data is available) may include fatigue Nausea Diarrhea Low blood cell counts (like neutropenia or anemia) And other common chemotherapy-related side effects. The specific side effects and their frequency are still being determined in ongoing clinical studies.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT06239467 Phase 1
Recruiting
First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer
United States, Belgium, France, Italy, South Korea, Spain