Amxt1501

Other Medications

EU Experimental ES Not available 1 Clinical Trials

Description

Amxt1501 is an investigational medication (meaning it is still being studied and not yet approved for any use) that was explored in clinical trials for certain types of cancer, including advanced solid tumors and DIPG/DMG (a type of brain tumor). It was studied in combination with another investigational drug called DFMO. The goal of the clinical trials was primarily to assess the safety and tolerability of this combination. Researchers also wanted to understand how the drugs affect the body (pharmacokinetics and pharmacodynamics) and look for early signs of effectiveness (biomarkers). The trials aimed to find the highest safe dose of Amxt1501 that could be used in combination with DFMO. These trials have been terminated.

Mechanism of Action

Amxt1501 is a prodrug of dicaprate. It is designed to be taken orally. In the body, it is converted to dicaprate, which is thought to affect polyamine metabolism. Polyamines are substances involved in cell growth and division. By interfering with polyamine uptake, the drug combination aims to potentially slow down the growth of cancer cells. The specific details of how Amxt1501 works are still being investigated.

Side Effects

As Amxt1501 is an investigational drug and the trials have been terminated Specific side effect data is limited. However Like many medications Amxt1501 could potentially cause side effects. The clinical trials focused on evaluating the safety and tolerability of the drug combination So researchers would have been monitoring patients closely for any adverse events. More information about potential side effects would typically come from completed clinical trial reports Which may not be fully available or detailed for terminated trials.

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT05500508 Phase 1
Terminated
Oral AMXT 1501 Dicaprate in Combination With IV DFMO
United States, Australia

Quick Info

CategoryOther Medications
EU EMA StatusExperimental
ES Spain AccessNot available
Clinical Trials1
View Clinical Trials Back to Drug Glossary

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Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult your healthcare team before making treatment decisions.