Description
AMG 404 is an investigational medication being studied by Amgen. It is being evaluated in clinical trials for certain types of advanced solid tumors, including colorectal cancer. Specifically, trials are looking at its use in patients whose tumors have a specific type of KRAS mutation called p.G12C. AMG 404 is being tested alone and in combination with other cancer treatments (like chemotherapy, targeted therapy, or immunotherapy) to see if it is safe and effective. It is important to note that AMG 404 is not yet approved for use in colorectal cancer and is only available as part of a clinical trial.
Mechanism of Action
AMG 404 is designed to target a specific protein within cancer cells that is altered by the KRAS p.G12C mutation. By targeting this protein, AMG 404 aims to disrupt the signals that tell the cancer cells to grow and divide. The specific protein targeted by AMG 404 is being characterized in clinical trials.
Side Effects
Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.