AlloStim (AlloStim)

Other Medications

US Experimental EU Experimental ES med_spain_not_available Intramuscular 3 Clinical Trials
T-cell activation pathways tumor-associated antigens

Description

AlloStim is a personalized immunotherapy that utilizes allogeneic T-cells to stimulate anti-tumor immune responses in patients with metastatic colorectal cancer. This cellular immunotherapy is designed to enhance the patient's immune system recognition and destruction of cancer cells. AlloStim can be administered as monotherapy or in combination with cryoablation procedures to create an in-situ vaccine effect at tumor sites.

Mechanism of Action

AlloStim works by introducing allogeneic (donor-derived) T-cells that have been processed to stimulate the patient's immune system against tumor antigens. The treatment aims to overcome immune tolerance and activate both innate and adaptive immune responses against colorectal cancer cells, particularly in patients with KRAS and BRAF mutations where traditional targeted therapies may be less effective.

Molecular Targets

Side Effects

Injection site reactions Fatigue Fever Chills Headache Nausea Muscle aches Temporary flu-like symptoms

Not all side effects are listed. Side effects vary by individual. Always consult your oncologist.

Clinical Trials

NCT04444622 med_phase_prefix2
Completed
Immunotherapy for Third Line Metastatic Colorectal Cancer
United States
NCT02380443 med_phase_prefix2
Archived
AlloStim® Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer
United States
NCT01065441 med_phase_prefix1
Archived
Experimental Therapeutic Cancer Vaccine Created In-situ in Patients With Stage II-Stage IV Cancer
Israel